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All raw data produced in this study (including NHPCA and mouse neocortex data) have been deposited to the CNGB Nucleotide Sequence Archive (accession code CNP0001469). All NHPCA count matrix data are available from: https://doi.org/10.5281/zenodo.3338948. The NHPCA website ( ) is an open and interactive database for exploration. The public datasets used in this study can be accessed as described below: the HCL count matrix is available at https://doi.org/10.5281/zenodo.3338948 , the MCA count matrix is available at https://doi.org/10.5281/zenodo.5435866 and the count matrix for the Tabula Muris dataset is available at https://doi.org/10.5281/zenodo.27733 . The Gene Expression Omnibus (GEO) accession numbers for the two human kidney datasets are GSE121862 and GSE151302. The GEO accession number for the mouse kidney data is GSE107585. The GEO accession number for the human neocortex data is GSE97942. The human heart data can be accessed at the European Nucleotide Archive ( ) using accession number ERP123138. The mouse heart data can be found through accession number E-MTAB-7869 in the database of the European Bioinformatics Institute ( -MTAB-7869/). Summary statistics files for each human trait were downloaded from the UK Biobank database or published studies (data links in Supplementary Table 6a). Source data are provided with this paper.
The Genome Association Project (GAP) data on human health outcomes were downloaded from gnomAD (v2.1.2) using the gnomAD gnomAD2 manifest. Summary statistics files for each of the 10 traits were downloaded from the Genome Analysis Toolkit (GATK) website (v3.4-46).
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License, where it is legal to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
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One of the drawbacks to this approach was that we needed to recompile every time we made even a small change to the code. This slowed everything else we were doing down and because we couldn't always have someone waiting for the application to finish building. 827ec27edc