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Enhanced in situ electrochemiluminescence immunoassay to analyze the therapeutic effects of cetuximab in human colorectal cancer SW480 cell xenograft model.
In recent years, much effort has been devoted to the rapid diagnosis and analysis of treatment efficacy of targeted drugs, such as cetuximab, in cancer therapy. In this study, a highly selective in situ electrochemiluminescence (ECL) immunoassay strategy is introduced for quantitative analysis of the tumor response. A cetuximab-modified bovine serum albumin (BSA) functionalized gold electrode is prepared to perform the ECL immunoassay. The cetuximab biomarker is conjugated to the BSA-conjugated gold electrode, providing an immunosensor with a good specificity and sensitivity for sensitive detection of the cetuximab protein with a linear range of 0.05-8.0 μg/mL and a detection limit of 0.05 μg/mL. The whole immunoassay can be completed within 30 min, and the assay has a good stability and reproducibility. The application of the developed electrochemical immunosensor in SW480 cells demonstrates that the cetuximab protein can be specifically detected in real time with high sensitivity. The established electrochemical immunosensor may offer a promising approach for the analysis of disease condition and therapeutic efficacy of novel drugs in clinical trials.Q:
mysql max value if it satisfies a certain condition
I'm trying to get the latest record from a table for every ID. If one record has a certain ID value, it's the latest one for that ID. If there are multiple records with that ID, I want the newest record. What query would do that?
I already have this query that doesn't work:
SELECT MAX(ImageTextSize) AS ImageTextSize
WHERE TextFileId 0b46394aab